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Review Article
Year: 2016 I  Volume: 5 I  Issue: 3I  Pages: 855
Molecular mechanisms of exercise in the cardiovascular system
Dr. Katharina Kirsch, Dr. Marcus Sandri
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany


Exercise training has become an established evidence-based therapeutic strategy with prognostic benefits for patient swith cardiovascular disease. In stable coronary artery disease, exercise training decelerates disease progress ion by positive lyinfluencing cardiovascular disease risk factors (i.e., hyperlipidemia and hypertension), coronary endothelial function, and endothelial regeneration. In chronic heart failure with reduced ejection fraction, exercise training prevents the progressive loss of exercise capacity by antagonizing skeletal muscle catabolism and left ventricular reverse remodeling with reduction in cardiomegaly and improvement of ejection fraction. New fields for exercise interventions include heart failure with preserved ejection fraction (HFpEF), pulmonary hypertension, and valvular heart disease. In HFpEF, studies indicate a lusitropic effect of training on diastolic function associated with an improvement of exercise capacity. In pulmonary hypertension, reduced pulmonary artery pressure is observed following an exercise training program. Recently, innovative training methods such as high-intensity interval training, resistance training, and others have been established. In this review, we provide an overview of the prognostic and symptomatic benefits of exercise training in the most prevalent cardiac disease entities.

Molecular mechanisms
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Print ISSN: 2249-4308
Online ISSN: 2277-6559
Frequency: Quarterly
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