Yoga is a holistic lifestyle and includes healthy diet (sattvic diet), physical exercise, stress management, and tobacco control, and, hence, it could be called as a lifestyle polypill. Yoga is becoming increasingly popular throughout the world because of its health benefit. Even the United Nations has realized its importance and has declared June 21 as the International Day of Yoga. Many studies suggest that the yoga lifestyle may be helpful in controlling risk factors for coronary heart disease life hypertension, type II diabetes mellitus, dyslipidemia, inflammation, oxidative and psychosocial stress, obesity, and smoking. A recent scientific statement of the American Heart Association has concluded that meditation could be considered as an alternative approach to lower blood pressure in all individual with blood pressure levels more than 120/80 mmHg. Yoga has also been shown to be beneficial in the secondary prevention of coronary heart disease, cardiac rehabilitation, cardiac arrhythmias, and congestive heart failure. Yoga may even regress early and advanced atherosclerosis. However, there are several limitations of the reported studies, and methodologies are generally poor. Large multicenter, well-planned randomized trials are needed to confirm these findings. However, as yoga is a cost-effective, simple holistic lifestyle without any sideeffects, it could be recommended for primary and secondary prevention of cardiovascular disease and it can play a primary and complimentary role in this regard.