Journal of Preventive Cardiology
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Review Article

Year: 2016 I  Volume: 6I  Issue: 1I  Pages:973–976
 
Non-high density lipoprotein cholesterol: a superior cardiovascular risk factor?
Dr. S C Manchanda, MD, DM
Sr. Consultant Cardiologist, Sir Ganga Ram Hospital, New Delhi

 

Abstract

Dyslipidemia is the single most important risk factor for development of coronary heart disease (CHD) and low density lipoprotein cholesterol (LDL-C) has been considered as the key risk factor for causing atherosclerosis and a primary target for lipid lowering therapy. However, there is a significant residual risk of 70–80% even after intensive LDL-C lowering by statins. Recently, it has been shown that non-HDL-C (which includes all atherogenic lipoproteins) has a distinct advantage over LDL-C in predicting CHD, especially when triglycerides are high. Non-HDL-C is simple to calculate and can be estimated in non-fasting state. Numerous epidemiological studies have demonstrated the superiority of non-HDL-C over LDL-C in predicting CHD and residual risk. Hence, many recent lipid guidelines have suggested that HDL-C must be calculated for prediction of cardiovascular risk and a treatment target, especially when triglycerides are high.

 
Keywords
Dyslipidemia
LDL-C
Residual risk
LDL-C Particle number
Triglycerides
 
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Journal of Preventive Cardiology
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Print ISSN: 2249-4308
Online ISSN: 2277-6559
 
Frequency: Quarterly
 
 
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